Nuclear extracts from K-562 cells stimulated with 5 g TPA were assayed for activity of AP1 family . Activating Transcription Factor 3 Regulates Canonical Activation of transcription factor IL-6 (NF-IL-6) and nuclear factor-B (NF-B) by lipid ozonation products is crucial to interleukin-8 gene expression in human airway epithelial cells Activating transcription factor 2 (ATF2) is a transcription factor of the leucine zipper family of DNA-binding proteins, discovered in 1991 by Ozawa et al. We have previously shown that silencing of ATF2 leads to a loss in the growth-inhibitory effects of tamoxifen in the oestrogen receptor (ER)-positive . ER stress is sensed by 3 ER transmembrane receptors, activating transcription factor 6 (ATF6), inositol-requiring kinase 1 (IRE1), and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK). The CREB (or CREB/ATF) family of transcription factors includes three homologous genes : creb, cAMP response element modulator (crem), and activating transcription factor-1 (atf-1). The regulatory role of activating transcription factor 2 in inflammation. Activating transcription factor 3 deficiency promotes cardiac hypertrophy, dysfunction, and fibrosis induced by pressure overload. (1999) obtained a partial cDNA encoding ATF5. CREB belongs to the activating transcription factor family (ATF), and as the name of this family implies most members are activators of gene transcription. Nucleophosmin (NPM1/B23) and the activating transcription factor 5 (ATF5) are both known to subject to cell type-dependent regulation. 18 studies have reported the regulative function of atf3 in the progress of tumor Here we followed-up on our previous observation that inhibition of Hsp90 may increase ATF3 expression and sought to determine the role of ATF3 in colon . MeSH information. . 24 . Activating transcription factor 4 (ATF4) belongs to the ATF/CREB (activating transcription factor/cyclic AMP response element binding protein) family of basic region-leucine zipper (bZip) transcription factors, which have the consensus binding site cAMP responsive element (CRE). We investigated the utility of measuring ATF3 expression as a marker of response to the HDACi pracinostat in bladder cancer models. Activation can be due to factors that interact at specific promoters, thereby increasing transcription directed by these promoters. Diseases associated with ATF3 include Bone Cancer and Hypospadias.Among its related pathways are TCR Signaling (Qiagen) and Myometrial Relaxation and Contraction Pathways.Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. J Neurosci 25, 3889-3899. ATF4 has numerous dimerization partners. Since ADM is an initial step in the progression to pancreatic ductal adenocarcinoma (PDAC . First, they have been described as members of the CREB/ATF family, whereas it turned out later that some of them might be more similar to AP-1 -like factors such as c-Jun or c-Fos. Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism. Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Link/Page Citation 1. The cytoplasmic protein Keap1 interacts with and represses Nrf2 function. The Ca (2+) -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6. transcription factor activating transcription factor 3 (atf3) is located on chromosome 1q32.3; as a member of the activating transcription factor family, when induced by stress, atf3 is able to regulate processes of metabolism, immunity, and carcinogenesis. Repressors decrease transcription. Transcription factors are members of the proteome as well as regulome . "Activating Transcription Factor 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). ATF3 (Activating Transcription Factor 3) is a Protein Coding gene. Computational approaches were developed to identify factors that modulate Nrf2 in a mouse liver gene expression compendium. (1989) obtained cDNAs encoding ATF1 through ATF8. Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Downregulation of activating transcription factor 5 is required for differentiation of neural progenitor cells into astrocytes. Activating Transcription Factor 6. These proteins initiate a signaling and transcriptional network termed the unfolded protein response (UPR), which re-establishes . activating transcription factor 1 (AP-1) motif is important in determining the up-regulatory effects induced by leptin on aromatase expression in MCF-7 breast cancer cells identification of its target genes as a chimeric protein with EWS The cytokines TNFalpha and GM-CSF activate CAEV transcription, and this effect occurs independently of AP-1. Here, we targeted expression of ATF4 to the OCL lineage using the Trap promoter or through deletion of Atf4 in mice. Cheong J, Coligan JE, Shuman JD. There are three different splice variants of CREB found in the brain, , , and . Activating transcription factor 6 (ATF6) is located within the region of linkage to type 2 diabetes on chromosome 1q21-q23 and is a key activator of the endoplasmic reticulum stress response. The unfolded protein response (UPR) is activated in pancreatic pathologies and suggested as a target for therapeutic intervention. Can both act as an activator or a repressor depending on the context. The transcription factor Nrf2 (encoded by Nfe2l2) induces expression of numerous detoxifying and antioxidant genes in response to oxidative stress. Disadvantages: requires specific antibody to the transcription factor of interest. Product Number Clonality Application Species Reactivity Citations SDS; SAB4500895: polyclonal: ELISA, WB: human, rat, mouse: 5: Pricing: HPA030187: ATF3 (activating transcription factor 3) is a member of the mammalian activation transcription factor/cAMP-responsive element-binding (CREB) family. We evaluated 78 single nucleotide polymorphisms (SNPs) spanning >213 kb in 95 people, from which we selected 64 SNPs for evaluation in 191 Caucasian case . Transcription factors control when, where, and how efficiently RNA polymerases function. Activators are the transcription factors that bind to the enhancer regions, activating the transcription by facilitating the binding of RNA polymerase and/or basal transcription factors to the . Human Ortholog ATF5, activating transcription factor 5. Activating transcription factor 3 (ATF3) is a member of the ATF/cAMP response element binding protein (CREB) family of transcription factors and contains a basic region and a leucine zipper . PMID 9712902 : TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage. transcription factor, molecule that controls the activity of a gene by determining whether the gene's DNA (deoxyribonucleic acid) is transcribed into RNA (ribonucleic acid). [ 46 ] and located on human chromosome 2q32. The deduced 122-amino acid protein contains a C-terminal . Activating complex network of embryonic signaling pathways, including Wnt, Notch, hedgehog and transforming growth factor- pathways, lead to the upregulation of EMT activating transcription factors, crucial for normal tissue development and maintenance. Adv Nutr 3, 307-321. Bacteria use a variety of mechanisms to direct RNA polymerase to specific promoters in order to activate transcription in response to growth signals or environmental cues. The enzyme RNA polymerase catalyzes the chemical reactions that synthesize RNA, using the gene's DNA as a template. To determine the in vivo function of ATF4, the ATF4 gene in murine embryonic stem cells was deleted and homozygous mutant mice were . Enhancers turn the genes "on" upon binding of transcription factors while silencers turn the genes "off" upon binding transcription factors. REVIEW EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness Ester Sanchez-Tillo Yongqing Liu Oriol de Barrios Laura Siles Lucia Fanlo Miriam . Crossref, Medline, Google Scholar; Baird TD, Wek RC (2012). Activating transcription factor 4 (ATF4) is a critical transcription factor for osteoblast (OBL) function and bone formation; however, a direct role in osteoclasts (OCLs) has not been established. Activating transcription factor 4 (ATF4) is a stress response gene involved in homeostasis and cellular protection. NPM1 is expressed weakly in hepatocytes and highly expressed in hepatocellular carcinomas (HCC) with a clear correlation between enhanced NPM1 expression and increased tumor grading and poor prognosis, whereas in contrast, ATF5 is expressed abundantly in . In this study, we examined activating transcription factor 3 . The unfolded protein response (UPR) is activated in pancreatic pathologies and suggested as a target for therapeutic intervention. However, the expression and function of ATF4 in gastric cancer MDR remains unknown. Activating Transcription Factor 3. Activating transcription factor 6 regulated cell growth, migration and inhibiteds cell apoptosis and autophagy via MAPK pathway in cervical cancer. The complex formed with MBD1 and SETDB1 represses transcription and . An activating transcription factor (ATF)-binding site is a promoter element present in a wide range of viral and cellular genes. Activating transcription factor 4 (ATF4), which regulates genes associated with endoplasmic reticulum stress, apoptosis, autophagy, the gut microbiome, and metabolism, has been implicated in many diseases. ATF3 is a transcription factor involved in cell growth, apoptosis, and invasion and is induced by a variety of anticancer and dietary compounds. Atf3 expression was detected throughout aging but increased expression in mTECs at 4-months and 10-months of age. Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress - Gastroenterology Original Research Full Report: Basic and TranslationalAlimentary Tract | Volume 159, ISSUE 4, P1357-1374.e10, October 01, 2020 Transcription factors are trans-acting regulatory proteins, determining the time, location, and the efficiency of transcription. However, its exact role in cancer is discussed controversially because both tumor suppressive and oncogenic effects have been described. In this study, we investigate whether ATF4 play a role in gastric cancer MDR and its potential mechanisms. Activating transcription factor (ATF)3 regulates the expression of inflammation-related genes in several tissues under pathological contexts. (1999) obtained a partial cDNA encoding ATF5. The cytoplasmic protein Keap1 interacts with and represses Nrf2 function. However, during prolonged activation . Using a yeast 2-hybrid screen with CDC34 (116948) as the bait, Pati et al. Factor Activation 10.1101/535096 For the first time we introduce the use of dynamic measurements of a transcription factor activation as a method to stratify patients and we are confident that our approach will lead in future to early patient stratification and prediction of treatment outcome. Activators and repressors are two types of transcription factors that regulate the gene expression at the transcriptional level. Activated transcription factor 6 (ATF-6) is an ER sensor protein of endoplasmic reticulum (ER) and an important regulator of apoptotic and autophagy pathway triggered by ERS. Transcription factors are proteins that help turn specific genes "on" or "off" by binding to nearby DNA. activating transcription factor 2 Synonyms ATF-2, Creb2, CRE-BP, D130078H02Rik, mXBP In our study, we analyzed datasets of atherosclerosis from the NCBI-GEO (Gene Expression Omnibus) database and found that expression . The transcription factor Nrf2 (encoded by Nfe2l2) induces expression of numerous detoxifying and antioxidant genes in response to oxidative stress. 20 Its nearest homolog, cAMP response element binding protein (CREB) has been much more extensively studied and is thought to be the major cAMP activated transcription factor, regulating key metabolic genes, for example, gluconeogenesis 21 - 23 and lipoprotein lipase. The expression of activating transcription factor 3 (ATF3), a stress-responsive transcription factor, is upregulated in the GI tissues of stressed animals. 1998 Aug 28;273(35):22714-8. Activating transcription factor 3 (ATF3) is a member of the ATF/cAMP response element-binding protein family of transcription factors. While both CREBs and . Background/Purpose: Activating transcription factor 3 (ATF3), a member of the activating transcription factor/cAMP-responsive element binding protein (ATF/CREB) family of transcription factors is induced by various types of cellular stress including oxidative stress.Here, we analyzed ATF3 as a downstream mediator of TGF- signaling in fibroblast activation and tissue fibrosis in systemic . We found that activating transcription factor 3 (Atf3) was highly expressed in all three cell types compared with the ectodermal cells. ATF3-deficient mice displayed an exacerbated phenotype of GI injuries. If you need a quick and simple method to study activation of factors such as NFkB, FOXO1 or c-myc, our assays can give you the answer in less than four hours. By screening a lambda-expression library with a DNA probe containing 3 tandem ATF-binding sites, Hai et al. Activating transcription factor, ATF, is a group of bZIP transcription factors, which act as homodimers or heterodimers with a range of other bZIP factors. Activating transcription factor 3 (ATF3) is an early response gene that is activated in response to atherosclerotic stimulation and may be an important factor in inhibiting the progression of atherosclerosis. Pracinostat treatment of bladder cancer cell lines reactivated the expression . Activating transcription factors (ATFs), or cAMP response element-binding proteins (CREBs), bind to cAMP-inducible promoters and are involved in gene transcription. Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. DNA bending protein brings the activators into the proximity of the promotor where additional transcription factors are bound and interact with the activators. However, its exact role in breast cancer endocrine resistance is still unclear. Synonyms ATFX, HMFN0395 . ATF3, a basic leucine zipper transcription factor, has long been recognized as a cellular adaptive response factor. Activating transcription factors are epigenetic regulators of specific genes. TFs work alone or with other proteins in a complex, by promoting (as an activator ), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme that performs the transcription of genetic information from DNA to RNA) to specific genes. We investigated possible participation of each of the three arms of the UPR and found that only the activating transcription factor 6 (ATF6) arm was selectively activated after induction of GFP-b(5)tail expression; peak ATF6 activation preceded the increase in phosphatidylcholine synthesis. In response to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen, three ER transmembrane signaling proteins, inositol-requiring enzyme 1 (IRE1), PRKR-like ER kinase (PERK), and activating transcription factor 6 (ATF6), are activated. In addition, the CREB-related factor activating transcription factor-4 (ATF4) has been shown to interact directly with GABA B R1 in neurons, and we show that ATF4 differentially regulates GABA B R1a and GABA B R1b promoter activity. Transcription factors that are activators boost a gene's transcription. Activating transcription factor-2 (ATF2), a member of the leucine zipper family of DNA binding proteins, has been implicated as a tumour suppressor in breast cancer. Transcription factor ATFx, cAMP-dependent transcription factor ATF-5, ATF5, Activating transcription factor 5, Cyclic AMP-dependent transcription factor ATF-5, Anti-activating transcription factor 5. "Activating Transcription Factor 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Loss of activating transcription factor 3 (ATF3) expression is a feature of bladder tumor progression and correlates with poor survival. Activating Transcription Factor 6. Activating transcription factor 4 (ATF4) also serves as a master regulator of the UPR that activates the induction of downstream UPR genes . ATF5, activating transcription factor 5 Vertebrate Orthologs 4 Vertebrate Orthology Source. MeSH information. Nucleophosmin (NPM1/B23) and the activating transcription factor 5 (ATF5) are both known to subject to cell type-dependent regulation. Transcription factors at the promotor recruit RNA polymerase and transcription can proceed. Cardiac Fibroblast-Specific Activating Transcription Factor 3 Promotes Myocardial Repair after Myocardial Infarction Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Multiple Mechanisms Converging on Transcription Factor EB Activation by the Natural Phenol Pterostilbene December 2021 Oxidative Medicine and Cellular Longevity 2021(8, article 119041):1-19 Groups of transcription factor binding sites called enhancers and silencers can turn a gene on/off in specific parts of the body. Cloning and Expression Using a yeast 2-hybrid screen with CDC34 ( 116948) as the bait, Pati et al. We studied the role of the Activating Transcription Factor 3 (ATF3) during thymic involution. In skeletal muscle, atf3 expression increases after exercise, but its target genes remain unknown. These genes generate a group of highly homologous proteins that have been named after their prototypes: CREB, CREM, and ATF-1, respectively . However, the effect of ATF3 on cardiac hypertrophy induced by a pathological stimulus has not been determined. We examine the range of architectures found at activator-dependent promoters and outline the . "Activating Transcription Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Activating transcription factor-3 (ATF3) is involved in the complex process of cellular stress response. Introduction Inflammation functions as a subcomponent of the immune response, which is a system of cells and tissues that evolved to maintain the boundaries between specialized cell populations and tissues of multicellular organisms. "Activating Transcription Factor 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Activating transcription factors (ATFs), or cAMP response element-binding proteins (CREBs), bind to cAMP-inducible promoters and are involved in gene transcription. The UPR is thus a complex program that coordinates several signaling pathways. Computational approaches were developed to identify factors that modulate Nrf2 in a mouse liver gene expression compendium. Importantly, ATF4 transactives tribbles homolog 3 (TRB3), a UPR-inducible gene , which can affect adipogenesis . Activating transcription factor 4 (ATF4), a key mediator of the ISR, and has been reported to induce the expression of genes involved in cellular homeostasis. J Biol Chem. There are many genes that fall under the ATF category, including ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, ATF7, and ATFx, Generally speaking, all ATFs are believed to be highly responsive to extracellular signals. In the present study, we investigated its role in salt-sensitive hypertensive mice. Activation of transcription factor IL-6 (NF-IL-6) and nuclear factor-B (NF-B) by lipid ozonation products is crucial to interleukin-8 gene expression in human airway epithelial cells Alliance of Genome Resources. Here, we report that Atf3 is expressed in medullary thymic epithelial cells (mTECs) and cortical thymic epithelial cells (cTECs). In this study, wxe examined Activating Transcription Factor 3 (ATF3), a mediator of the UPR which promotes acinar-to-ductal metaplasia (ADM) in response to pancreatic injury. Background: Activating transcription factor 5 (ATF5) is a member of the activating transcription/cAMP response element-binding protein family of basic leucine zipper proteins that plays an important role in cell survival, differentiation, proliferation, and apoptosis. In this study, we directly measured the expression of ATF3 and inflammatory factors in human coronary atherosclerotic plaques to examine the relationship between ATF3 expression . Mechanically, activating transcription factor 3 (ATF3) was identified as the key differentially expressed gene in Crls1-HKO mice through transcriptomic analysis, and our investigation further showed that CRLS1 suppresses ATF3 expression and inhibits its activity in palmitic acid-stimulated hepatocytes, whereas ATF3 partially reverses lipid . ATF4: activating transcription factor 4; ATF6: activating transcription factor 6; IRE1: inositol-requiring enzyme 1; NRF2: nuclear factor (erythroid-derived 2-) like 2; P-eIF2: phosphorylated eukaryotic initiation factor 2; PERK: protein kinase RNA-like endoplasmic reticulum kinase; UPR: unfolded protein response; XBP1: X-box-binding protein-1. In adipocytes, ATF3 inhibits adipogenesis and induces adipocyte browning ( 14 ). It plays a role in inflammation and innate immunity, and suggests that ATF3 is associated with atherosclerosis. Previously, our laboratory identified activating transcription factor 3 (ATF3) as up-regulated by nonsteroidal anti-inflammatory drugs using microarray analysis of mRNA from human colorectal cancer cells treated with sulindac sulfide. Activating transcription factor-2 regulates phosphoenolpyruvate carboxykinase transcription through a stress-inducible mitogen-activated protein kinase pathway. Multiple Mechanisms Converging on Transcription Factor EB Activation by the Natural Phenol Pterostilbene December 2021 Oxidative Medicine and Cellular Longevity 2021(8, article 119041):1-19 However, its mechanistic role in hypertension remains unclear. MeSH information. NPM1 is expressed weakly in hepatocytes and highly expressed in hepatocellular carcinomas (HCC) with a clear correlation between enhanced NPM1 expression and increased tumor grading and poor prognosis, whereas in contrast, ATF5 is expressed abundantly in . ATF - or Activating Transcription Factor - refers to a specific group of bZIP transcription factors. We aimed to identify those genes and to determine the influence of ATF3 on muscle adaptation to training. Ng,2,9 Coleen Damcott,10 Alan R. Shuldiner,10 Eleftheria Zeggini,8 and Steven C. Elbein1 Activating . Activating transcription factor 3 (ATF3), which is encoded by an adaptive-response gene induced by various stimuli, plays an important role in the cardiovascular system. ATF-1 is named for activating transcription in response to cyclic-AMP. Activating transcription factor (ATF) 4 is a ubiquitous basic leucine-zipper transcription factor that is a member of the ATF/cyclic adenosine monophosphate responsive element-binding (CREB) protein family. In macrophages, ATF3 inhibits inflammatory response and mediates the anti-inflammatory effects of HDL ( 11 - 13 ). 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